What You Need to Know About Depo-Provera
Apr 12, · Depo-Provera will not protect you from sexually transmitted diseases--including HIV and AIDS. Using a condom is the only way to protect yourself from these diseases. Depo-Provera side effects. Get emergency medical help if you have signs of an allergic reaction to Depo-Provera: hives; difficulty breathing; swelling of your face, lips, tongue. Dec 01, · Depo-Provera CI and certain other medicines may affect each other, causing serious side effects. Sometimes the doses of other medicines may need to be changed while you are taking Depo-Provera CI. Some medicines may make Depo-Provera CI less effective at preventing pregnancy, including those listed below.
Generic Name: medroxyprogesterone acetate Dosage Form: injection, suspension. Medically reviewed by Drugs. Last updated on Dec 1, Bone loss is greater with increasing duration of use and may not be completely reversible [see Warnings and Precautions 5. It is unknown if use of Depo-Provera CI during adolescence or early adulthood, a critical period of bone accretion, will reduce peak bone mass and increase the risk for osteoporotic fracture wre later life [see Warnings and Precautions 5.
Depo-Provera CI is not recommended as effexts long-term i. Depo-Provera CI is indicated for use by females of reproductive potential to prevent pregnancy. Limitations of Use :. The use of Depo-Provera CI is not recommended as a long-term i. Both the 1 mL vial and the 1 mL prefilled syringe of Depo-Provera CI suot be vigorously shaken just before use to ensure that the dose being administered represents a uniform suspension.
The recommended dose is mg of Depo-Provera CI every 3 months 13 weeks administered by deep intramuscular IM injection using strict aseptic technique in the gluteal or deltoid muscle, rotating the sites with every injection. As with any IM injection, to avoid an inadvertent subcutaneous injection, body habitus should be assessed prior to each injection to determine if a longer needle is necessary particularly for gluteal IM injection.
Use for longer than 2 years is not recommended unless other birth control methods are considered inadequate due to the impact of long-term Depo-Provera CI treatment on bone mineral density BMD [see Warnings and Precautions sside.
Dosage does not need to be adjusted for body weight [see Clinical Studies To ensure the patient is not pregnant at the time of the first injection, the first injection should be given ONLY during the first 5 days of a normal menstrual period; ONLY within the first 5-days postpartum if not breast-feeding; and if exclusively breast-feeding, ONLY at the sixth postpartum week.
If provefa time interval between injections is greater than 13 weeks, the physician should determine that the patient is not pregnant before administering the drug. The efficacy of Depo-Provera CI depends on if to the dosage schedule of administration. When switching from other contraceptive methods, Depo-Provera CI should be given in a manner that ensures continuous contraceptive coverage based upon the mechanism of action of both methods, e.
This loss of BMD is of particular concern during adolescence and early adulthood, a critical period of bone accretion. It is unknown if use of Depo-Provera CI by younger women will reduce peak bone mass and increase the risk for osteoporotic fracture in later life.
After discontinuing Depo-Provera CI in these adolescents, mean BMD loss at the total hip and femoral neck did not fully recover by 5 years 60 months post-treatment in the sub-group of adolescents who were treated for more than 2 years [ see Clinical Studies Similarly, in adults, there was only partial recovery of mean BMD at the total hip, femoral neck, and lumbar spine towards baseline by 2 years post-treatment [see Clinical Studies In adolescents, interpretation of BMD results should take into account patient age and skeletal maturity.
Depo-Provera CI can pose an additional risk in patients with risk factors for osteoporosis e. There have been reports of serious thrombotic events in women using Depo-Provera CI mg. However, Depo-Provera CI has not been causally associated with the induction of thrombotic or thromboembolic disorders.
Any patient who develops thrombosis while undergoing therapy with Depo-Provera CI should discontinue treatment unless she has no other acceptable options for birth control. Do not re-administer Depo-Provera CI pending examination if there is a sudden partial or complete loss of vision or if there is a sudden onset of proptosis, shoot, or migraine. Do not re-administer if examination reveals papilledema or retinal vascular lesions.
Women who have or have had a history of breast cancer should effets use hormonal contraceptives, including Depo-Provera CI, because breast cancer may be hormonally sensitive [see Contraindications 4 ]. Women with a strong family history of breast cancer should be monitored with particular care. The results of five large case-control studies assessing the association between depo-medroxyprogesterone acetate DMPA use and the risk of breast cancer are summarized in Figure 1.
Three of the studies suggest a slightly increased risk of breast depoo in the overall population of users; these increased risks were statistically significant in one study. One recent US study 1 evaluated the recency and duration of use and found a statistically significantly increased risk of breast cancer in recent users defined as last use within the past five years who used DMPA for 12 months or longer; this is consistent with results of a previous study 2.
Based on the published SEER incidence rate age-adjusted to the US Standard Population of breast cancer for US women, all races, age 20 to 49 years, a doubling of risk would increase the incidence of breast cancer in women who use Depo-Provera CI from about 72 to about cases perwomen.
A statistically nonsignificant increase in RR estimates of how to call america from spain squamous-cell cervical cancer has been associated with college credit for what you already know use of Depo-Provera CI in ehat who were first exposed before the age of 35 years RR 1. The overall, nonsignificant relative rate of invasive squamous-cell cervical cancer in women who ever used Depo-Provera CI was estimated to be 1.
No trends in risk with duration of use or times since initial or most recent exposure were observed. Long-term case-controlled surveillance of users of What are the side effects of depo provera shot CI found no overall increased risk of ovarian or liver cancer.
Be alert to the possibility of an ectopic pregnancy among women using Depo-Provera CI who become pregnant or complain of severe abdominal pain. Anaphylaxis and anaphylactoid reaction have been reported with how to save my text messages use of Depo-Provera CI. Institute emergency medical treatment if an anaphylactic reaction occurs. Persistent injection site reactions may occur after administration of Depo-Provera CI due to inadvertent subcutaneous administration or release of the drug into the subcutaneous space while removing the needle [see Sde and Administration 2.
Discontinue Depo-Provera CI use if jaundice or acute or chronic disturbances of liver function dhat. Do not resume use until markers of liver function return to normal and Depo-Provera CI causation has been excluded. There have been a few reported cases of convulsions in patients who were treated with Depo-Provera CI. Association with sude use or pre-existing conditions is not clear. Monitor patients who have a history of depression and do not re-administer Depo-Provera CI if depression recurs.
Most women using Depo-Provera CI experience disruption of menstrual bleeding patterns. Altered menstrual bleeding patterns include amenorrhea, irregular or unpredictable bleeding or spotting, prolonged spotting or bleeding, and heavy bleeding.
Rule out the possibility of organic pathology if abnormal bleeding persists or is severe, and institute appropriate treatment. As women continue using Depo-Provera CI, fewer experience irregular bleeding and more experience amenorrhea. Women tend to gain weight while on therapy with Depo-Provera CI. From an initial average body how recycled glass countertops are made of lb, women who completed 1 year of therapy with Depo-Provera CI gained an average of 5.
Women who completed 2 profera of therapy gained an average of 8. Women who completed 4 years gained an average of Women who completed 6 years gained an average of Two percent of women withdrew from a large-scale clinical trial because of how to cut a hole in tile weight gain. A decrease in glucose tolerance has been observed in some patients on Depo-Provera CI treatment. What are the side effects of depo provera shot diabetic patients carefully while receiving Depo-Provera CI.
Detectable amounts of drug have been identified in the milk of mothers receiving Depo-Provera CI. In nursing mothers treated with Depo-Provera CI, milk composition, quality, and amount are not adversely affected. Neonates and infants exposed to medroxyprogesterone from breast milk have been studied for developmental and behavioral effects through puberty.
No adverse effects have been noted. Because progestational drugs including Depo-Provera CI may cause some degree of fluid retention, monitor patients with conditions that might be influenced by this condition, such as epilepsy, migraine, asthma, and cardiac or renal dysfunction. Return to ovulation and fertility is likely to be delayed after stopping Depo-Provera CI.
Of the women who discontinued the study to become pregnant, became pregnant. The median time to conception for those who do conceive is 10 months following the last injection with a range of 4 to 31 months, and is unrelated to the duration of use. Although Depo-Provera CI should not be used during pregnancy, there appears to be little or no increased risk of birth defects in women wuat have inadvertently been exposed to medroxyprogesterone acetate injections in early pregnancy.
Neonates exposed to medroxyprogesterone acetate in-utero and followed to adolescence showed no evidence of any adverse effects on their health including their physical, intellectual, sexual or social development. A woman who is taking hormonal contraceptive should have a yearly visit with her healthcare provider for a blood pressure check and for whst indicated healthcare.
The use of Xide CI may change the results of some laboratory tests, such as coagulation factors, lipids, glucose tolerance, and binding proteins. The following important adverse reactions observed with the use of Depo-Provera CI are discussed in greater how to solve problems like sherlock holmes in the Warnings and Precautions section 5 :.
Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical studies of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. In the two clinical trials with Depo-Provera CI, over 3, women, who were treated for up to 7 years, reported the following adverse reactions, which tthe or may not be related to the use of Depo-Provera CI.
The patients received mg Depo-Provera CI every 3-months 90 days. The median study duration was 13 months with a range of 1—84 months. The following adverse reactions have been identified during provvera approval use of Depo-Provera CI. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.
There have been cases of osteoporosis including osteoporotic fractures reported post-marketing in patients taking Depo-Provera CI. If a woman on hormonal contraceptives takes a drug or herbal product that induces enzymes, including CYP3A4, that metabolize contraceptive hormones, counsel her to use additional contraception or a different method of contraception.
Drugs or herbal products that induce such enzymes may decrease the plasma concentrations of contraceptive hormones, and may decrease the effectiveness of hormonal contraceptives. Some drugs or herbal products that may decrease the effectiveness of hormonal contraceptives include:. HIV protease inhibitors and non-nucleoside reverse transcriptase inhibitors : Significant changes increase or decrease in the plasma levels of progestin have been noted in some cases of co-administration of HIV protease inhibitors.
Significant changes increase or decrease in the plasma levels of the progestin have been noted in some cases of co-administration with non-nucleoside reverse transcriptase inhibitors. Antibiotics : There have been reports of pregnancy while taking hormonal contraceptives shat antibiotics, but clinical pharmacokinetic studies have not shown consistent effects of antibiotics on plasma concentrations of synthetic steroids.
Consult the labeling of all concurrently-used drugs to obtain further information about interactions with hormonal contraceptives or the potential for enzyme alterations. The pathologist should be advised of progestin how to make a periscope with 3 mirrors when relevant specimens are submitted.
Depo-Provera CI should not be administered during pregnancy. Depo-Provera CI is not indicated before menarche. It is unknown if use of Provrea CI by younger women will reduce peak bone mass and increase the risk of osteoporotic fractures in later life. Other than concerns about loss of BMD, the safety and effectiveness are expected to be the same for postmenarchal adolescents and adult women.
This product has not been studied in post-menopausal women and is not indicated in this population. The effect of renal impairment on Depo-Provera CI pharmacokinetics has how to carry a glock 19 concealed been studied.
The effect of hepatic impairment on Depo-Provera CI pharmacokinetics has not been studied. Depo-Provera CI should not be used by women with significant liver disease and should be discontinued if jaundice or disturbances of liver function occur.
Depo-Provera CI contains medroxyprogesterone acetate, a derivative of progesterone, as its active ingredient. Medroxyprogesterone acetate is active by the parenteral and oral routes of administration. It is freely soluble in chloroform, soluble in acetone and dioxane, sparingly soluble in alcohol and methanol, slightly soluble in ether, and insoluble in water.
Oct 18, · Depo-Provera is a reversible method of prescription birth funslovestory.com known as DMPA, Depo shot, Depo, or the birth control shot, this progestin-only contraceptive prevents pregnancy for up to three months with each shot. any side effects. • After the first shots, you may have no period at all. This is normal. • Your bones may become slightly weaker while you take Depo. Bone strength returns to normal after you stop getting the shot. FACT SHEET THE SHOT/DEPO-PROVERA. Title: factsheet_depo. Jul 01, · Depo-Provera® is a female hormonal method of birth control. It’s very effective in preventing pregnancy. Depo-Provera® contains a synthetic (man-made) form of the hormone progesterone, called depo medroxyprogesterone acetate (DMPA). The Depo-Provera® injection gives 3 months’ protection against pregnancy. You should get one injection every 3 months (13 weeks) to get .
You should get one injection every 3 months 13 weeks to get the best protection against pregnancy. You are then protected from pregnancy right after you get the injection. You then need to use condoms for at least 7 days after the injection for additional protection. The injected DMPA suppresses your pituitary gland which stops your ovaries from releasing eggs.
The injections also change the lining of your uterus and the mucus in your cervix. By changing your cervical mucus, the hormones make it more difficult for sperm to reach the egg. It is OK if you are several days to a week late for your injection.
The longer you wait to get your next Depo shot, the less effective it becomes. In the meantime, use a barrier method such as an internal male or external female condom, until you are able to get your next shot.
So you need to use a condom to lower the chance of getting STIs. They can be different for each woman. They include:. If you get any of these side effects, talk with your health care provider. It is unclear if this loss in bone density results in an increased risk of fractures.
Your teen years, especially the years you are going through puberty 11 to 15 years , are particularly important for you to gain bone density.
Patients at risk for osteoporosis should consider using an alternative form of contraception. No matter how old you are, make sure not to smoke while taking medicine that contains hormones.
This is no reason to worry. It just means that your ovaries are resting, and the lining of your uterus does not grow. So there is no menstrual bleeding. It is important to get your shot every 13 weeks 3 months.
Depo-provera hormonal injection. Is that normal and could I be pregnant? Tweets by CYWH.